香港六合彩

团队介绍：

乳品科学与技术研究团队，现有教师6名，其中教授/研究员2名，副教授/副研究员3名，讲师1名。围绕乳品基础科学与应用技术研究领域开展了多项创新性工作。同时，研究团队积极服务区域产业，团队成员为宁波市个人及团队特派员，通过深入产业研发及生产一线，将产业前沿技术与生产实际进行高效互动。解决了宁波当地企业乳酸菌饮料加工关键风味指纹图谱的构建与产品开发、区域发酵制品中功能菌株筛选与产业应用等难题。入选国家级人才1人，浙江省杰出青年人才1人，宁波市人才3人。近五年团队成员主持国家科技计划、国家自然科学基金、浙江省杰出青年基金、浙江省重点研发计划课题等项目20余项，在《Trends in Food Science and Technology》、《Food Chemistry》、 《Food Hydrocolloids》、 《Journal of Agricultural and Food Chemistry》和《Food Control》等食品SCI TOP期刊发表论文50余篇，授权发明专利30余件，以第一完成单位先后获教育部科技进步一等奖、浙江省科学技术奖二等奖、浙江省自然科学二等奖、宁波市科技进步奖三等奖等科技奖项。

团队特色：

针对乳品加工领域的国家需求和地方生命健康产业发展导向，本团队（方向）重点要解决的关键问题是：

1）发酵制品产业中的核心乳酸菌菌株特性研究与功能应用；

2）多元菌株发酵过程中的SIM（Single in Mix）技术开发；

3）特征性乳酸菌代谢产物的鉴定与互作分析；

4）乳酸菌及功能性乳蛋白及肽的营养功能评价技术；

5）乳品原料及发酵乳检测前端关键技术集成应用。

团队拥有千余株自主产权的功能性发酵菌株，申请包括多种发酵乳制品、干酪产品、液态奶、功能性乳饮料等乳业科技相关专利30余件。

主要研究方向：

研究团队主要研究方向聚焦功能性乳酸菌及其代谢产物的筛选与评估；益生乳酸菌发酵剂及功能性发酵制品研发；乳源生物活性物质挖掘与制备；功能性配方多元蛋白乳制品的产品开发；原料乳及乳品加工过程中关键危害因子溯源及快速检测。

代表性科研成果：

(1) Mingjuan Ou, Jiamiao Lou, Lifeng Lao, Yuxing Guo, Junwu Ji, Daodong Pan, Zhen Wu*. Plant-based meat analogue of the soybean proteins by the multi-strain solid-state mixing fermentation; Food Chemistry; 2023, 414 (15), 135671.

(2) Du, Qiwei.; Tu, M.; Liu, J.; Ding, Y.; Zeng, X.; Pan, D., Plant-based meat analogs and fat substitutes, structuring technology and protein digestion: A review. Food Research International 2023, 112959.

(3) Zhang, Tao.; Guo, Y.; Fan, X.; Liu, M.; Xu, J.; Zeng, X.; Sun, Y.; Wu, Z.; Pan, D., Protection Mechanism of Metal Ion Pre-Stress on Lactobacillus acidophilus CICC 6074 under Acid Tolerance. J Agric Food Chem 2023, 71 (36), 13304-13315.

(4) Tao, Zhang.; Yujie, Y.; Xiaoqun, Z.; Zhen, W.; Daodong, P.; Haibo, L.; Mingxuan, T.; Weijun, W.; Yuxing, G., Protective mechanism of milk fat globule membrane proteins on Lactobacillus acidophilus CICC 6074 under acid stress based on proteomic analysis. Food Chemistry 2023, 434, 137297.

(5) Du, Qiwei.; Wu, Y.; Zeng, X.; Tu, M.; Wu, Z.; Liu, J.; Pan, D.; Ding, Y., Competitive binding of maltodextrin and pectin at the interface of whey protein hydrolyzate-based fish oil emulsion under high temperature sterilization: Effects on storage stability and in vitro digestion. Food Research International 2022, 164, 112368.

(6) Lifeng Lao, Guo Yang, Ao Zhang, Lianliang Liu, Yuxing Guo, Liwei Lian, Daodong Pan, Zhen Wu*. Anti-inflammation and gut microbiota regulation properties of fatty acids derived from fermented milk in DSS-induced colitis mice. Journal of Dairy Science；2022, 105(10), 7865-7877.

(7) Muhammad Salman Farid, Rameesha Anjum, Yiping Yang, Maoling Tu, Tao Zhang, Daodong Pan, Yangying Sun, Zhen Wu*. Recent trends in fermented plant-based analogues and products. Trends in Food Science & Technology, 2024 (149) , 104529.

(8) Fengxuan Lang, Jianzhu Wen, Zhen Wu*, Daodong Pan*, Linjun Wang. Evaluation of probiotic yoghurt by the mixed culture with Lactobacillus plantarum A3；Food Science and Human wellness; 2021, 11(2), 323-331.

(9) Maolin Tu, Hanxiong Liu, & Ming Du. Identification and analysis of transepithelial transport properties of casein peptides with anticoagulant and ACE inhibitory activities. Food Research International, 2020, 138, 109764.

(10) Cai, Zhendong.; Wang, P.; Guo, Y.; Zeng, X.; Wu, Z.; Pan, D., S-layer protein modulates the stimulatory effects of Lactobacillus acidophilus CICC 6074 by triggering PKC signaling cascade in RAW 264.7 cells. Journal of Functional Foods, 2020, 67, 103841.

(11) Lan, Hangzhen., Hartonen, K., Riekkola, M.L. Miniaturised air sampling techniques for analysis of volatile organic compounds in air. TrAC Trends in Analytical Chemistry, 2020, 126, 115873.

(12) Lan, Hangzhen., Holopainen, J., Hartonen, K., Jussila, M., Ritala, M., Riekkola, M.L. Fully automated online dynamic in-tube extraction for continuous sampling of volatile organic compounds in air. Analytical Chemistry, 2019, 91 (13) 8507-8515.

(13) Lan, Hangzhen., Zhang, W., Smått, J.H., Koivula, R., Hartonen, K., Riekkola, M.L. Selective extraction of aliphatic amines by functionalized mesoporous silica-coated solid phase microextraction Arrow. Microchimica Acta, 2019, 186 (7), 412.

(14) Maolin Tu, Shuzhen Cheng & Ming Du. Advancement and prospects of bioinformatics analysis for studying bioactive peptides from food-derived protein: sequence, structure, and functions. Trends in Analytical Chemistry,2018, 105, 7-17.

(15) Liu, Rilong, Hangzhen Lan, Zhen Wu, Daodong Pan, and Hanqing Yang. A triple lateral flow strip assay based on multiplex polymerase chain reaction for simultaneous detection of chicken, pork and duck in adulterated meat. Journal of Food Composition and Analysis 137 (2025): 106968..

(16) Jiang, Senwei, Hangzhen Lan, Zhen Wu, Daodong Pan, and Yichun Wu. Adsorption of alkylphenols by post-modified UiO-66: Adsorption characteristics and mechanism. Journal of Molecular Structure 1322 (2025): 140422.

(17) Yang, Peixun, aoyan Zhu, Hangzhen Lan, Yichun Wu, and Daodong Pan. Electrospun of functionalized mesoporous UiO-66 as the selective coating of solid phase microextraction Arrow for the determination of nine alkylphenols. Microchimica Acta, 191 (2024) 188.

(18) Yang, Peixun, Senwei Jiang, Zhen Wu, Daodong Pan, and Hangzhen Lan. Core-shell MIL-53 (Al)–NH2@ UiO-66 coated solid-phase microextraction Arrow for the selective enrichment of nine alkylphenols in milk. Microchemical Journal, 207 (2024) 111874.

(19) Yan, Song, Cuiling Li, Hangzhen Lan, Daodong Pan, and Yichun Wu. Comparison of four isothermal amplification techniques: LAMP, SEA, CPA, and RPA for the identification of chicken adulteration, Food Control, 159 (2024) 110302.（ESI高被引论文）

(20) Li, Xueying, Mengfei Chen, Hangzhen Lan, Daodong Pan, and Yichun Wu. Carboxyl-functionalized mesoporous silica-coated solid-phase microextraction Arrow for the determination of six biogenic amines in animal-derived meat, Journal of Food Composition and Analysis, 132 (2024) 106263.

(21) Li, Cuiling, Hangzhen Lan, Zhen Wu, and Daodong Pan. Identification of horse ingredients based on recombinase polymerase amplification, high-throughput DNA isolation and magnetic separation, Food Control, 167 (2024) 110837.

(22) Feng, Jinchao, Hangzhen Lan, Zhen Wu. Novel integration of lateral flow strip and pointof-care isothermal amplification techniques for meat adulteration detection: a comprehensive review, Trends in Food Science & Technology, 152 (2024) 104698.

(23)Jinchao Feng, Hangzhen Lan, Daodong Pan, Xiahong Xu, Yichun Wu. Development of a duplex recombinase polymerase amplification-lateral flow strip assay with 1 min of DNA extraction for simultaneous identification of pork and chicken ingredients, Journal of Food Composition and Analysis, 132 (2024) 106253.

(24) Xuanhua Du, Man Lu, Hangzhen Lan, Zhendong Cai, Daodong Pan, Yichun Wu. Development of a high-throughput DNA isolation method for livestock and poultry meat based on mesoporous metalorganic framework-coated solid-phase microextraction device, Journal of Food Composition and Analysis, 127 (2024) 105977.

(25) Xuanhua Du, Hangzhen Lan, Zhen Wu, Daodong Pan, Yichun Wu. Two-dimensional metal-organic framework nanosheets coated solid-phase microextraction Arrow coupled with UPLCQ-ToF-MS for the determination of three veterinary residues in milk and pork, Journal of Chromatography A, 1736 (2024) 465373.

(26)Jinchao Feng, Hangzhen Lan, Daodong Pan. Triplex-colored nucleic acid lateral flow strip and multiplex polymerase chain reaction coupled method for quantitative identification of beef, pork and chicken, Journal of Food Composition and Analysis, 123 (2023) 105493.

(27) Song Yan, Hangzhen Lan, Zhen Wu, Yangying Sun, Maolin Tu & Daodong Pan. Cleavable molecular beacon-based loop-mediated isothermal amplification assay for the detection of adulterated chicken in meat, Analytical and Bioanalytical Chemistry, 414 (2022) 8081-8091.

(28) Man Lu, Hangzhen Lan, Zhendong Cai, Zhen Wu, Yangying Sun, Maolin Tu & Daodong Pan. Rapid solid phase microextraction of DNA using mesoporous metal–organic framework coating for PCR based identification of meat adulteration, Microchimica Acta, 189 (2022) 433.

(29) Yaxin Yin, Jue Xu, Zihang Shi, Daodong Pan, Zhen Wu, Xiaoqun Zeng, Maolin Tu. (2025). Research on the preparation of soy protein isolate and whey protein isolate composite nanoparticles and their characteristics in high internal phase Pickering emulsions. Food Chemistry, 477, 143476.

项目：

(1) 宁波市重点研发计划-浙东特色发酵制品品质提升关键技术与智能装备集成应用，250万

(2) 浙江省杰出青年科学基金-群体感应介导植物乳杆菌与肠道营养小分子的互作机制研究，80万

(3) 国家自然科学基金面上项目-乳杆菌LPxTG结构蛋白介导群体感应下菌体的胃肠适应机制，58万

(4) 国家自然科学基金面上项目-乳杆菌表面多功能蛋白介导氨基酸衍生代谢物在酸乳发酵中的调节机制，50万

(5) 宁波市甬江人才工程项目-牛乳蛋白生物活性肽的高效制备关键技术研究及个性化营养食品开发，100万

(6) 国家自然科学基金青年项目-基于乳蛋白的界面行为解析n-3 PUFAs乳脂球促进酸乳凝胶化的作用机制，30万

(7) 国家自然科学基金青年项目-酪蛋白抗菌肽的构效关系及其基于菌外膜蛋白介导的抑菌机制研究，30万

(8) 国家自然科学基金青年项目-后修饰介孔有机框架材料对牛奶中烷基酚类化合物高选择性吸附的机理研究，30万

(9) 国家自然科学基金青年项目-富锰乳杆菌趋向乳脂肪球膜介导酸乳风味物质的形成与释放机制研究，30万

(10) 国家自然科学基金青年项目-细胞壁分选酶介导嗜酸乳杆菌的黏附效应研究，24万

(11) 宁波市甬江人才工程项目-乳双歧杆菌BB-12多层级微乳液的稳定机制及功能性特色酸奶研制，100万

(12) 浙江省重点研发计划课题-真假农产品真实性现场快速诊断关键技术及产品研发-基于核酸与蛋白的农产品真实性现场快速诊断关键技术及产品研发，40万元

(13) 宁波市重点研发计划课题-混合化学危害物自动化样品前处理装备研发 ，25万元

(14) 浙江省市场监督管理局雏鹰计划课题-基于直接电离质谱技术的农产品化学危害物自动化快检体系研究与示范 ，20万元

(15) 香港六合彩开奖网 高级别科技项目培育-量子点介导磁性 MOF调控食源性致病菌靶向识别与多模式信号响应机制研究 ，20万元

奖励：

(1) 国家教育部科学技术进步奖一等奖，鸭鹅肉精深加工及其副产物综合利用技术创新与应用，2019；

(2) 浙江省科学技术奖二等奖，基于核酸适配体和纳米材料的食品安全快速检测方法和增敏机制，2020；

(3) 浙江省科学技术奖二等奖，乳酸菌及其发酵产品开发关键技术创新与应用, 2024;

(4)宁波市科技进步奖二等奖，乳酸菌及其发酵代谢产物开发利用关键技术研究及应用, 2024；

(5) 宁波市科技进步奖三等奖，水禽肉及其系列产品精深加工关键技术研究与应用，2018；

(6)宁波市科技进步奖三等奖，基于核酸适体和纳米材料的食品安全快速检测关键技术研和应用, 2020

专利：

(1) 一种复合发酵菌剂在制备发酵乳中的应用. 吴振，温健竹，陈梦琪，潘道东，夏强，曾小群，何俊. 授权专利号：ZL202110565741.4

(2)一种乳酸菌、筛选及应用. 吴振，瞿春晓，潘道东，蔡振东，曾小群，孙杨赢. 授权专利号：ZL201911127323.6

(3) 一种功能性嗜酸乳杆菌黏液结合蛋白的表达纯化及其应用. 吴振，潘道东，熊蓉露，曾小群，孙杨赢，蔡振东. 授权专利号：ZL 201811299290.9

(4)一种乳酪蛋白微胶囊、制备方法及应用. 吴振，纵曼利，潘道东，孙杨赢，劳立峰. 授权号：CN202210280987.1

(5)一种乳酸菌多功能蛋白及其制备方法. 吴振，叶倩文，潘道东，劳立峰，孙杨赢，夏强. 授权号：CN202210970861.7

(6)一种固相微萃取探针、制备方法及其在生物胺检测中的应用. 蓝航镇，陈梦飞，潘道东. 授权专利号：ZL 2022 1 0635603.3

(7)一种具有抑制α-葡萄糖苷酶和酪氨酸酶活性的功能性酸乳制品及其制备方法. 潘道东，吴振，曾小群，蔡振东，夏强. 授权专利号：ZL202010138550.5

(8)一种富多种功能因子水蜜桃花生复合风味酸奶及其制备方法. 潘道东，吴振，曾小群，郭宇星. 授权专利号：ZL201910554305.X

(9)A processing method of yoghourt rich in resveratrol and gamma-aminobutyric acid. 潘道东，吴振，曾小群，涂茂林，廉立伟. 授权专利号：PT_CP_ZA00005567

(10) A Functional Yogurt with a Compound Flavor of Coix chinensis Tod. and Setaria italica and a Preparation Method Thereof. 潘道东，郭宇星，曾小群，吴振. 授权专利号：PT_CP_ZA00005657

(11) A strain of Lactic acid bacteria producing Beta-glucosidase and its screening method and the preparation method of yogurt enriched with active flavonoid aglycones. 潘道东，吴振，刘青，曾小群，赵广生. 授权专利号：PT_CP_ZA00005325

(12) 提取DNA的试剂盒及DNA提取方法. 蓝航镇，陈梦飞，潘道东.授权专利号：ZL202210626821.0

(13) 用于同时鉴别12种肉源食品的多重PCR检测用引物组和方法.蔡振东，蓝航镇， 郭影琪，潘道东，曾小群，吴振，周松. 授权专利号：ZL202210174823.0

(14) 基于七重PCR技术的肉类检测用引物组和方法.蔡振东、蓝航镇、栾卉垚、潘道东、曾小群、吴振、周松. ZL202210176211.5